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KMID : 0384119910110010183
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Korean Journal of Clinical Pathology
1991 Volume.11 No. 1 p.183 ~ p.196
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A Study on T Cell Subsets and Natural Killer (NK) Cells of Peripheral Blood in Patients with Various Cancer
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J. Y. Han
S. H. Kim/H. C. Son/E. Y. Lee/J. M. Kim
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Abstract
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To elucidate alteration of peripheral T cell subsets and NK cell activity in patients with various cancer, the authors examined CD3+, CD4+, CD8+ and Leu 7+ cells and NK cell activity in 20 cases of thyroid cancer, and 7 cases of uterine cervical cancer as well as 23 cases of adult healthy subjects as controls. The diagnoses were confirmed histopathologically in all patients. Blood samples were obtained from veins of the patients and control subjects at Pusan National University Hospital during the period from January to August, 1990. The results obtained were summarized as follows : 1. The percentage of CD3+ and CD4+ cells, and CD4/CD8 ratio were significantly decreased, and the percentage of CD8+ cells was significantly increased in patients with gastrointestinal tract cancer, lung cancer, and cervical cancer as compared with control subjects respectively. 2. In the patients with thyroid cancer, the percentage pf CD4` cell and CD4/CD8 ratio were significantly increased and CD8+ cells was significantly decreased as compared with control subjects. 3. The percentage of Leu 7+ cells tended to be increased only in patients with the gastrointestinal tract cancer as compared with control subjects. 4. The activity of NK cells was significantly decreased in all patients with various cancer. 5. The significant correlation between the absolute number of Leu 7` cells and NK cell activity was found only in the patients with gastrointestinal tract cancer. On the basis of these results, it can be suggested that the cellular immunosuppression in patients with gastrointestinal tract cancer, lung cancer, and cervical cancer is due to the decreased helper/inducer T cells and the increased suppressor/ cytotoxic T cells and the immunodysfunction in patients with thyroid cancer is due to the increased helper/inducer T cells and the decreased suppressor/ cytotoxic T cells. It can also be suggested that the activity of NK cells is decreased in all patients with various cancer.
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